Mast Cell Activation Syndrome (MCAS) is when the mast cells overreact to any stimulus causing what is called Mast Cell Activation Disease (MCAD) which is an inappropriate mast cell activation. Mast Cell Activation Disease (MCAD), occurs when the mast cells become dysfunctional, becoming hyperactive in their protection and detect minor events as an invasion. Mast cells are a type of white blood cell, immune/defense cells, that exist throughout the whole body. They exist in all the tissues; the bone, muscles, tendons, ligaments, circulatory system; affecting all the organs in the body, the tissues, the nerves, the sinuses, the respiratory system, the digestive system, and even the functioning of the brain. Mast cells control our immune system and regulate our healing, Mast cells, when detecting a problem such as an injury, virus or bacteria, mold, foreign material can react explosively, producing and releasing into the tissues and organs a wide range of potent chemical signals to help the body heal and recover.

Sometimes after the body goes through a traumatic event or a series of traumatic events the body can get stuck in a flight or fight mode becoming hyper-vigilant, creating hypersensitivity in the human body. When this occurs over a longer period of time it can progress into Mast Cell Activation Disease.

Now, I am sure many of you are wondering how candida or fungal infections can cause Mast Cell Activation Syndrome.

In the article, Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells, written by Jose Pedro Lopes, Marios Styliano, Gunnar Nilsson, & Constantin F. Urba, C. albican was shown to be a potent stimulator of mast cell activation. According to their publication, C. albican when attached mast cell from the outside "resulted in loss of membrane dye and thus integrity of the host cell membrane, clearly demonstrating that mast cells are ruptured by C. albicans. This, at least in part, explains the high mast cell death during interaction with C. albicans, because it is a more frequent event (in 15-20% of the cells). C. albicans can induce cell death in host cells."

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What I wish to emphasize is that at the root of many illnesses is an activation of the mast cells that can elevate to the point where the mast cells become over-active and hypervigilant, causing a whole host of symptoms.

Another point I wish to express is that Mast Cell Activation Disease is not picked up in routine lab testing and it often does not cause abnormalities. MCAD was not even recognized as an illness until 2007. Many allergy doctors are not even familiar with it. For instance, my general physician told me over the years that I just had "allergies". I was forming heavy phlegm in my lungs and bronchials, causing violent coughing that resulted in an umbilical hernia. When I went into the allergist they did elaborate IgE testing for everything with a skin test and to further verify results as a blood test. After all, this was completed, I was told that I was not allergic to anything. I was dumbfounded because if I got around dust or mold my nose would run and I would cough violently. I also would cough violently after I ate. Now I know that Mast Cell Activation Syndrome was the root cause of my illness and that my mast cells were creating high histamine levels, which was aggravated by eating high histamine foods.

MCAD is a chronic, multisystem illness that causes "histamine intolerance" causing excess histamine production and inflammation which can potentially affect every organ in the body. The result of this high histamine production is diamine oxidase (DAO) enzyme deficiency.

This is why we recommend supplementing with Histamine Digest PureMAX with DAO to reduce histamine and raise DAO levels.

With Mast Cell Activation Disease, healing is a slow, but steady process that can take months and even years. It is an illness that requires constant vigilance to recognize and treat the factors that caused a raised mast cell activity and careful dietary monitoring of low-histamine foods. Each individual is unique as to what is effective and ineffective and will need to stay aware of their own reaction to the environment, electronics, and food.

The following situations can be factors in developing Mast Cell Activation Syndrome or Multiple Chemical Sensitivity.

  • Intestinal infection or disease
  • Infections in the mouth, cavitations (infections in the jaw), mercury fillings, and mercury toxicity.
  • Exposure to RF (radio frequencies), wireless technology, cell phones, cell towers. Exposure to any device with SMPS (Switch Mode Power Supply). This can be from an electric smart meter, a new variable speed furnace, and yes... LED lighting (alternates between an AC and DC current.
  • Chemical Exposure. Herbicide and/or pesticide poisoning. Glycophate (Roundup) poisoning.
  • Heavy Metal Poisoning - toxic levels of mercury, lead, aluminum, chromium, cadmium, arsenic, etc.
  • Parasites
  • Malnutrition - poor absorption of nutrients
  • Mold exposure
  • Plastic toxicity
  • Fungal and/or candida infections
  • Having a severe bacterial or viral infection
  • Emotional trauma - divorce, death of loved one, financial problems, moving, war, a victim of violence, abuse.
  • Poor functioning gallbladder, liver, pancreas, and/or kidney. Unable to eliminate toxins effectively.

Symptoms of MCAS

  • Brain and Nervous System
    • Sleep - Deprivation/insomnia. Trouble falling asleep. Waking up with difficulty falling asleep again. Circadian rhythm disorder (sleep more during the day).
    • Mental symptoms - Depression, anxiety, brain fog, obsessive-compulsive disorder (OCD), fight or flight symptoms with high cortisol. memory issues.
    • Neurological symptoms - Pain around and on the crown of the head. Pain behind ears and in the neck. Dizziness, headaches. Hot flashes, or sweating. Neuropathic leg or arm pain.
  • Eyes
    • Dry, redness, itchy, sensitive, painful, tearing/watery, inflamed, vision blurry
  • Ears
    • Tinnitus. Sensitivity to certain sounds, frequencies, or vibrations. Blocked Eustachian tubes causing crackling of popping in ears.
  • Mouth
    • Swelling in the tongue, periodic formation of ulcers in the mouth, tooth sensitivity, severe allergies to dental materials - especially materials with metal in them (copper, zinc, lithium, tin, mercury amalgam, aluminum, beryllium, cadmium, chromium, nickel, gold, etc.), gum infection and/or inflammation
  • Throat and Larynx
    • Swallowing difficulties and throat tightness
  • Heart
    • Rapid heartbeat, low blood pressure, palpitations
  • Respiratory System
    • Congestion in the larynx, bronchial, and/or lung that can include heavy phlegm and coughing, especially after eating. Dry cough, shortness of breath, difficulty taking a deep breath, episodic asthma, wheezing, difficulty swallowing, runny nose, sinus congestion, frequent throat clearing, frequent sneezing
  • Liver and Gall Bladder
    • Bile production low, difficulty digesting fats, elevated liver enzymes
  • Gastrointestinal System 
    • Abdominal pain, cramping, bloating, irritable bowel syndrome (IBS), diarrhea, constipation, low acidity in the stomach causing acid reflux, poor absorption of nutrients, food sensitivities, allergies
  • Urinary Tract System
    • Frequent and urgent urination, Interstitial Cystitis with significant urinary tract symptoms and discomfort, but no documented urinary tract infection.
  • Reproductive System
    • Hormonal imbalance - body making too little or too much of a hormone, endometriosis, cramping during periods, infertility
  • Skin
    • Hives, itching, swelling, chills, psoriasis. rosacea, eczema, bruising, hair loss, hot flashes, sweating, slow healing
  • Hematologic System
    • Bruising and unusual nose bleeds
  • Bones and Muscles
    • Frequent tendon and ligament pain or injuries, hypermobility of the joints, arthritis that comes and goes, pain in the muscles and bones, bone loss, degenerative disk problems, tingling and numbness in the arm or fingers
  • Immune System
    • Frequent head colds or upper respiratory infections. Bacterial infections, such as bronchitis and sinus infection.
  • Environmental Symptoms
    • Sensitivity to mold, dust, resins from wood
  • Chemical Sensitivity
    • Sensitivity to pesticides, herbicides, cleaning solutions, perfumes, carpets, paints, latex, formaldehyde
  • Medications
    • Extreme reactions to many medicines
  • Electrical Sensitivity
    • Sensitivity to radio frequencies - wireless technology, smart appliances, cell phones, cell towers
    • Sensitivity to SMPS (switch mode power supply) devices - Smart electric meters, variable speed furnaces, LED lighting (alternate between AC and DC current)
    • Sensitivities to high magnetic fields
    • Sensitivities to electric fields
    • Sick after using the computer.
  • Other Symptoms
    • Frequently feeling poorly, fatigue, feeling cold all the time, swollen lymph nodes, possible anaphylactoid reactions, weak or rapid pulse 
  • Illnesses that may be related to MCAS
    • MCS (Multiple Chemical Sensitivity), IBS (Irritable Bowel Syndrome), Interstitial Cystitis, Fibromyalgia, Chronic Fatigue
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.
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